After that, starting at about the 3-month tag and carrying on for to a yr up, hyperpigmentation could be addressed. Alexis suggested. After the acne is under hyperpigmentation and control could be assessed alone, dermatologists may consider whether bleaching real estate agents work. If therefore, how? Bleaching agents could be effective, stated Dr. Alexis, who suggests lesion-directed instead of broad-field therapy, unless there are numerous bigger hyperpigmented macules. Coming down the street are topical nitric oxide preparations, which he stated are looking best for darker pores and skin in clinical trials. Alexis. Alexis reported economic human relationships with multiple pharmaceutical businesses.S.